The concept of radiosurgery was invented by the Swedish Professor of Neurosurgery Lars Leksell in 1951. It was he who first used the word radiosurgery. The idea behind radiosurgery was that it was more elegant to perform an operation without opening the head. After much preliminary research Professor Leksell settled on Gamma Rays as the best agent for performing radiosurgery. The term was devised as follows. In the opinion of Lars Leksell the procedure was a form of surgery, hence the use of the term 'surgery'. As it used radiation it was logical to call it radiosurgery. The subject had a slow start. From 1967 to 1983 there was only one site practising radiosurgery and that was in Stockholm. Then first in Buenos Aires and then in Sheffield radiosurgery centres were established. However, radiosurgery really took off when a Gamma Knife was established in Pittsburgh. The chief of neurosurgery there holds the Lars Leksell professorship in radiosurgery. There are now over 200 Gamma Knife radiosurgery centres round the world.


Lars Leksell
The Inventor of
the Gamma Knife

Why is it called Gamma Knife?
The definition Dr. Leksell gave to radiosurgery was a single session radiation treatment where radiation is delivered with surgical precision. Surgery is carried out with a knife. Since his machine uses Gamma rays it was a simple extra step to call it the Gamma Knife. As the reader can see this 19-ton machine does not look at all like a knife. But it is the machine’s function not its appearance, which justifies the use of the term.
What is Gamma Knife for?
Today safe neurosurgery is much more achievable than even 20 years ago. Better anaesthesia, improved lighting and the operating microscope have done much to improve the safety of neurosurgery. Even so the brain remains a major challenge for the physician practising neurosurgery. There are still regions where neurosurgery cannot reach. The places inside the brain where there is most risk are the deep central portions. In addition the skull base (that part of the skull the brain sits on) is also a hazardous area.

Danger areas
There are reasons why safe neurosurgery is hard to achieve at the base of the brain and the central region. The central part of the brain can be reached with accuracy today so it is not just the depth that is the problem. The difficulties are rather related to the way in which the brain is constructed. It is a reasonable analogy to suggest that the surface of the brain is like a computer while the deeper portions are like the wires. The computer may be more complex in its nature but its components are spread out so that a small amount of damage may pass unnoticed. The central wiring is compressed so that the wires (nerves) to many parts of the body are all compressed together in a tight space. This means that even a minor neurosurgery procedure could have very marked effects on the patient. Thus the centre of the brain is a risky area for the surgeon. The skull base is also risky because parts of it are inaccessible to neurosurgery. However, the major difficulties are related to the nerves and blood vessels, which are in part fixed and are very delicate and essential for normal function. Neurosurgery is much more difficult near these structures.

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